There is no cure for fever blisters. Medications that can relieve some of the pain and discomfort include ointments that numb the blisters,antibiotics that control secondary bacterial infections,and ointments that soften the crests of the sores.
Acyclovir, an antiviral drug, prevents the herpes simplex virus from multiplying and,in pill form, has been reported to reduce the symptoms and frequency of recurrence.